Drugs Triggering Peripheral Neuropathy

The primary route of reduction for tadalafil is via the hepatic cytochrome P450 isoenzyme CYP3A4, which metabolizes the drug to a catechol metabolite. The catechol metabolite undergoes intensive methylation to create the methylcatechol metabolite and then glucuronidation to the proper execution the methylcatechol glucuronide conjugate. The major circulating metabolite is the methylcatechol glucuronide, which is… Continue reading Drugs Triggering Peripheral Neuropathy